Short Answer: What plasma center pays the most? Donating plasma allows you to earn some extra cash while helping those in need, and most plasma donation centers have an ongoing need for donors. Below, we have more information about the requirements for donating plasma, plus the list of the highest-paying plasma donation centers. Food and Drug Administration FDA regulations limit plasma donation to twice in a seven-day period and once in a two-day period. Donors should be in good general health and feel well on the day of donation. You will need to undergo a pre-screening physical on your first visit to determine whether you are eligible to donate plasma. You can find a full explanation of blood donor qualifications, including whether a particular condition or circumstance exempts you from donating blood, on the Eligibility Criteria by Topic page of the American Red Cross website. Rates may vary according to a number of factors, including the location of the facility, donor weight, and ...